Postdoc in Neurodegeneration & Patient Specific iPSC Organoids

About the LCSB

The University of Luxembourg is an international research university with a distinctly multilingual and interdisciplinary character.

The Luxembourg Centre for Systems Biomedicine (LCSB) is an interdisciplinary research centre of the University of Luxembourg.
We conduct fundamental and translational research in the field of Systems Biology and Biomedicine - in the lab, in the clinic and in silico. We focus on neurodegenerative processes and are especially interested in Alzheimer's and Parkinson's disease and their contributing factors. The LCSB recruits talented scientists from various disciplines: computer scientists, mathematicians, biologists, chemists, engineers, physicists and clinicians from more than 50 countries currently work at the LCSB. We excel because we are truly interdisciplinary, and together we contribute to science and society.

Your role

We are seeking a highly motivated Postdoctoral Researcher to lead experimental work on patient iPSC-derived midbrain organoids, assembloids and chimeroids to investigate mechanisms of Parkinson's disease (PD). The work has a particular focus on high-throughput technologies and the analysis of protein aggregation. The project integrates stem cell biology, stress granule biology, multi-omics, and therapeutic target validation.

Key responsibilities:

• Generation, maintenance, and differentiation of human iPSCs into midbrain organoids, assembloids and chimeroids
• Design and execution of stress paradigms such as environmental, inflammatory, proteopathic, and stress hormone exposure
• High-content imaging, confocal microscopy, and quantitative image analysis
• Functional phenotyping using HD-MEA electrophysiology
• Testing of therapeutic strategies
• Coordination with single-cell RNA-seq, single-cell proteomics, and proximity proteomics workflows
• Supervision and mentoring of PhD students and technical staff
• Preparation of manuscripts, reports, and presentations for international conferences
• Active participation in a highly collaborative international consortium

Your profile

Required qualifications:

• PhD in neuroscience, stem cell biology, neurobiology, or a related field
• Strong experience with human iPSC culture and neural differentiation
• Solid background in cell biology, neurodegeneration, or RNA biology
• Proven ability to work independently, supervise team members and drive complex projects
  
  

Desirable skills:

• Experience with organoids or assembloids
• Familiarity with omics approaches such as scRNA-seq, proteomics
• Programming or data analysis skills such as R, Python, or similar
• Experience in international collaborative projects
• Experience with laboratory automation

We offer

• Multilingual and international character. Modern institution with a personal atmosphere. Staff coming from 90 countries. Member of the "University of the Greater Region" (UniGR)
• A modern and dynamic university. High-quality equipment. Close ties to the business world and to the Luxembourg labour market. A unique urban site with excellent infrastructure
• A partner for society and industry. Cooperation with European institutions, innovative companies, the Financial Centre and with numerous non-academic partners such as ministries, local governments, associations, NGOs …

How to apply

Applications should include:

• Curriculum Vitae
• Cover letter

Early application is highly encouraged, as the applications will be processed upon reception. Please apply ONLINE formally through the HR system. Applications by Email will not be considered.

All qualified individuals are encouraged to apply. In line with our values, the University of Luxembourg promotes an inclusive culture. We encourage applications from individuals of all backgrounds and are dedicated to upholding equality and respect for our employees and students.

General information:

• Contract Type: Fixed Term Contract 24 Month
• Work Hours: Full Time 40.0 Hours per Week
• Location: Belval Campus
• Internal Title: Postdoctoral researcher
• Job Reference: UOL08000

The yearly gross salary for every Postdoctoral Researcher at the UL is EUR 85176 (full time).